Blanco M D, García O, Trigo R M, Teijón J M, Katime I
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Biomaterials. 1996 Jun;17(11):1061-7. doi: 10.1016/0142-9612(96)85906-0.
The aim of this work was to test the application of new copolymeric poly (acrylamide-co-monomethyl itaconate) (A/MMI) hydrogels to 5-fluorouracil (5-FU) release. Three different compositions of copolymers have been studied, 90A:10MMI 75A:25MMI and 60A:40MMI. The equilibrium swelling degree in saline solution was between 76 and 80% depending on the copolymer composition. 5-FU, as the sodium salt, was trapped in the gels by including it in the feed mixture of polymerization. The swelling kinetics of the hydrogels in saline solution were studied at four temperatures, and the diffusion coefficient and the activation energy of the process were obtained. The 5-FU release as a function of temperature and disc load was studied; the diffusion coefficient and the activation energy of the release process were also obtained. The diffusion studies follow Fick's second law.
这项工作的目的是测试新型共聚聚（丙烯酰胺 - 共 - 衣康酸单甲酯）（A/MMI）水凝胶在5-氟尿嘧啶（5-FU）释放方面的应用。研究了三种不同组成的共聚物，90A:10MMI、75A:25MMI和60A:40MMI。在盐溶液中的平衡溶胀度在76%至80%之间，具体取决于共聚物的组成。5-FU作为钠盐，通过将其包含在聚合的进料混合物中而被包封在凝胶中。在四个温度下研究了水凝胶在盐溶液中的溶胀动力学，并获得了该过程的扩散系数和活化能。研究了5-FU释放量随温度和圆盘负载的变化情况；还获得了释放过程的扩散系数和活化能。扩散研究遵循菲克第二定律。
