• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Neuropathic pain sensations are differentially sensitive to dextrorphan.

作者信息

Tal M, Bennett G J

机构信息

Department of Anatomy, Hebrew University-Hadassah Dental and Medical School, Jerusalem, Israel.

出版信息

Neuroreport. 1994 Jul 21;5(12):1438-40. doi: 10.1097/00001756-199407000-00008.

DOI:10.1097/00001756-199407000-00008
PMID:7948833
Abstract

Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechanoallodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.

摘要

相似文献

1
Neuropathic pain sensations are differentially sensitive to dextrorphan.
Neuroreport. 1994 Jul 21;5(12):1438-40. doi: 10.1097/00001756-199407000-00008.
2
Neuropathic pain from an experimental neuritis of the rat sciatic nerve.大鼠坐骨神经实验性神经炎所致的神经性疼痛。
Pain. 1999 Nov;83(2):169-82. doi: 10.1016/s0304-3959(99)00102-5.
3
Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy.NMDA和非NMDA受体激活在周围性单神经病性疼痛大鼠热痛觉过敏的诱导和维持中的不同作用
Brain Res. 1992 Dec 11;598(1-2):271-8. doi: 10.1016/0006-8993(92)90193-d.
4
Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat.右啡烷可缓解大鼠神经性热诱发的痛觉过敏。
Neurosci Lett. 1993 Mar 5;151(1):107-10. doi: 10.1016/0304-3940(93)90058-s.
5
Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.鞘内注射MK-801与局部神经麻醉协同降低实验性周围单神经病大鼠的伤害性反应行为。
Brain Res. 1992 Apr 3;576(2):254-62. doi: 10.1016/0006-8993(92)90688-6.
6
Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy.在周围性单神经病大鼠模型中，鞘内注射右啡烷或氯胺酮可有效减轻疼痛相关行为。
Brain Res. 1993 Mar 5;605(1):164-8. doi: 10.1016/0006-8993(93)91368-3.
7
Magnesium suppresses neuropathic pain responses in rats via a spinal site of action.
Brain Res. 1994 Dec 15;666(2):168-72. doi: 10.1016/0006-8993(94)90768-4.
8
MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy.MK-801可阻断实验性疼痛性神经病变大鼠模型中热痛觉过敏的发展。
Brain Res. 1991 Jul 12;553(2):327-30. doi: 10.1016/0006-8993(91)90844-l.
9
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.脊髓 N-甲基-D-天冬氨酸受体拮抗剂对大鼠福尔马林致痛和神经损伤诱发的异常性疼痛的疗效。
J Pharmacol Exp Ther. 1997 Feb;280(2):829-38.
10
NMDA receptors are important for both mechanical and thermal allodynia from peripheral nerve injury in rats.
Neuroreport. 1997 Jul 7;8(9-10):2149-53. doi: 10.1097/00001756-199707070-00011.

引用本文的文献

1
Evidence For Cannabidiol Modulation of Serotonergic Transmission in a Model of Osteoarthritis via PET Imaging and Behavioral Assessment.通过正电子发射断层扫描成像和行为评估，在骨关节炎模型中证明大麻二酚对血清素能传递的调节作用
Int J Innov Res Med Sci. 2022 Jun;7(6):254-271. doi: 10.23958/ijirms/vol07-i06/1418. Epub 2022 Jun 3.
2
Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain.氧化锰纳米酶缓解部分坐骨神经切断诱导的神经病理性疼痛大鼠模型的机械性痛觉过敏。
Int J Nanomedicine. 2019 Dec 27;14:10105-10117. doi: 10.2147/IJN.S225594. eCollection 2019.
3
Neuropathic insult increases the responsiveness to acetic acid in mice.
神经性损伤会增加小鼠对醋酸的反应性。
Behav Pharmacol. 2019 Sep;30(6):534-537. doi: 10.1097/FBP.0000000000000486.
4
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.大麻二酚调节血清素传递，逆转神经病理性疼痛模型中的痛觉过敏和焦虑样行为。
Pain. 2019 Jan;160(1):136-150. doi: 10.1097/j.pain.0000000000001386.
5
Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.钠离子通道 Na(v)1.7 对于降低烧伤损伤后的热痛阈值是必不可少的。
J Neurosci. 2012 Aug 8;32(32):10819-32. doi: 10.1523/JNEUROSCI.0304-12.2012.
6
After-effects of consecutive sessions of transcranial direct current stimulation (tDCS) in a rat model of chronic inflammation.连续经颅直流电刺激（tDCS）对慢性炎症大鼠模型的后效影响。
Exp Brain Res. 2012 Aug;221(1):75-83. doi: 10.1007/s00221-012-3149-x. Epub 2012 Jul 3.
7
Central sensitization: a generator of pain hypersensitivity by central neural plasticity.中枢敏化：通过中枢神经可塑性产生疼痛超敏反应的机制
J Pain. 2009 Sep;10(9):895-926. doi: 10.1016/j.jpain.2009.06.012.
8
TREK-1, a K+ channel involved in polymodal pain perception.TREK-1，一种参与多模式疼痛感知的钾离子通道。
EMBO J. 2006 Jun 7;25(11):2368-76. doi: 10.1038/sj.emboj.7601116. Epub 2006 May 4.
9
Long-term changes in behavior and regional cerebral blood flow associated with painful peripheral mononeuropathy in the rat.大鼠外周单神经病性疼痛相关的行为和局部脑血流的长期变化。
Pain. 2002 Jan;95(1-2):31-40. doi: 10.1016/s0304-3959(01)00370-0.
10
Glutamate receptors and nociception: implications for the drug treatment of pain.谷氨酸受体与伤害感受：对疼痛药物治疗的启示
CNS Drugs. 2001 Jan;15(1):29-58. doi: 10.2165/00023210-200115010-00004.