Sato K, Kandori H, Sato S
Drug Safety Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
J Pharmacol Toxicol Methods. 1994 Aug;31(4):191-8. doi: 10.1016/1056-8719(94)90003-5.
Left ventricular pressure (LVP) in free-moving rats was continuously measured for 2 weeks by a telemetry blood pressure measurement system. Prior to LVP measurement, a dummy transmitter was used to determine whether organ weights, including that of the heart and the lungs, or the stiffness of the left ventricular chamber were affected by the catheterization of the LV chamber. Organ weights did not increase, and no functional abnormalities were observed in the left ventricular pressure-volume relationship. The LVP transmitter was implanted in the left ventricle, and systolic LVP, end-diastolic LVP, LV dP/dt max, and heart rate were measured. All parameters were essentially stable during the 2-week observation period after implantation, and the values, especially the heart rate, in the dark phase tended to be higher than those in the light phase. Microscopic examination of the left ventricular wall revealed that implantation of the dummy or LVP transmitter caused no histological damage. We confirmed that LVP in free-moving rats can be measured continuously for 2 weeks without any harmful effect on cardiac function and that this telemetry system should be useful in pharmacological and toxicological studies.
通过遥测血压测量系统对自由活动大鼠的左心室压力（LVP）连续测量2周。在测量LVP之前，使用一个假发射器来确定包括心脏和肺在内的器官重量或左心室腔的硬度是否受左心室腔插管的影响。器官重量没有增加，并且在左心室压力-容积关系中未观察到功能异常。将LVP发射器植入左心室，并测量收缩期LVP、舒张末期LVP、左心室dP/dt max和心率。植入后2周观察期内所有参数基本稳定，并且在暗期的值，尤其是心率，往往高于明期。对左心室壁的显微镜检查显示，假发射器或LVP发射器的植入未造成组织学损伤。我们证实，自由活动大鼠的LVP可以连续测量2周，而对心脏功能没有任何有害影响，并且这种遥测系统应该在药理学和毒理学研究中有用。
