Tranchand B, Ardiet C, Bouffet E, Biron P, Philip I, Nasri F, Brunat-Mentigny M
Centre Léon-Bérard, Lyon, France.
Bull Cancer. 1994 Jan;81(1):43-6.
In order to perform melphalan dosage adjustment, the linearity of melphalan kinetics was studied, in the case of previous carboplatin administration. Eleven patients with various solid tumors entered the present study. Carboplatin was administered during 5 days over 1-hour infusions; the day after, the melphalan test-dose was administered and followed 24 hours after by the complement dose. Melphalan kinetics were determined from only three plasma samples by using bayesian estimation. The present study showed that previous carboplatin administrations induced wide variations of melphalan pharmacokinetic parameters between the two administrations. As part of this protocol, the order of drug administration should be taken into account, in order to perform melphalan dosage adjustment.
为了进行美法仑剂量调整，研究了在先前给予卡铂的情况下美法仑动力学的线性。11例患有各种实体瘤的患者进入本研究。卡铂在5天内进行1小时输注给药；之后一天，给予美法仑试验剂量，并在24小时后给予补充剂量。通过贝叶斯估计仅从三个血浆样本中确定美法仑动力学。本研究表明，先前给予卡铂会导致两次给药之间美法仑药代动力学参数出现广泛变化。作为该方案的一部分，为了进行美法仑剂量调整，应考虑药物给药顺序。
