Notch 信号通路在牙齿发育和成人牙髓细胞中的作用。
Notch signalling pathway in tooth development and adult dental cells.
机构信息
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu.
出版信息
Cell Prolif. 2011 Dec;44(6):495-507. doi: 10.1111/j.1365-2184.2011.00780.x. Epub 2011 Oct 4.
Abstract
Notch signalling is a highly conserved intercellular signal transfer mechanism that includes canonical and non-canonical pathways. It regulates differentiation and proliferation of stem/progenitor cells by means of para-inducing effects. Expression and activation of Notch signalling factors (receptors and ligands) are critical not only for development of the dental germ but also for regeneration of injured tissue associated with mature teeth. Notch signalling plays key roles in differentiation of odontoblasts and osteoblasts, calcification of tooth hard tissue, formation of cusp patterns and generation of tooth roots. After tooth eruption, Notch signalling can also be triggered in dental stem cells of the pulp, where it induces them to differentiate into odontoblasts, thus generating fresh dentine tissue. Other signalling pathways, such as TGFβ, NF-κB, Wnt, Fgf and Shh also interact with Notch signalling during tooth development.
摘要
Notch 信号通路是一种高度保守的细胞间信号转导机制，包括经典和非经典途径。它通过旁诱导效应调节干细胞/祖细胞的分化和增殖。Notch 信号通路因子（受体和配体）的表达和激活不仅对牙原基的发育至关重要，而且对与成熟牙齿相关的损伤组织的再生也至关重要。Notch 信号通路在成牙本质细胞和成骨细胞的分化、牙体硬组织的矿化、牙尖形态的形成和牙根的发生中发挥关键作用。牙萌出后，牙髓中的牙髓干细胞也可以被 Notch 信号通路激活，诱导其分化为成牙本质细胞，从而产生新的牙本质组织。在牙齿发育过程中，其他信号通路，如 TGFβ、NF-κB、Wnt、Fgf 和 Shh 等，也与 Notch 信号通路相互作用。
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