Afanas'ev S A, Alekseeva E D, Bardamova I B, Bogomaz S A
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):24-6.
The efficacy of emoxypine (2-ethyl-6-methyl-3-hydroxypyridine chlorohydrate) versus sodium hydroxybutyrate in total and local ischemia followed by reperfusion was studied in the experiments on rat isolated hearts. Emoxypine in a dose of 1 nM in total ischemia was shown to have a protective action, by decreasing reperfusion contracture. In local ischemia, emoxypine, unlike sodium hydroxybutyrate, did not favour greater restoration of the amplitude of isolated heart contractions, but restored coronary flow and stabilized contraction frequency better than did sodium hydroxybutyrate.
在大鼠离体心脏实验中，研究了依莫昔平（2-乙基-6-甲基-3-羟基吡啶氯水合物）与羟丁酸钠对全心缺血及局部缺血再灌注的疗效。结果表明，在全心缺血时，剂量为1 nM的依莫昔平可通过减少再灌注挛缩发挥保护作用。在局部缺血时，与羟丁酸钠不同，依莫昔平虽不有助于离体心脏收缩幅度的更大恢复，但在恢复冠脉血流和稳定收缩频率方面优于羟丁酸钠。
