[实验中羟丁酸钠和艾莫昔芬对肾上腺素损伤心肌功能状态的作用]
[The action of sodium oxybutyrate and emoxypin on the functional state of the adrenaline-damaged myocardium in an experiment].
作者信息
Sysoliatina N A, Artamonova V V
机构信息
Institute of Veterinary Medicine, Agrarian University, Omsk, Russia.
出版信息
Eksp Klin Farmakol. 1998 Mar-Apr;61(2):30-2.
The effect of agents possessing antihypoxic and antioxidant activity, namely sodium oxybutyrate and emoxypin, on the functional state of the heart muscle was studied in experiments on dogs with epinephrine necroses of the myocardium. A marked cardioprotective effect was produced by sodium oxybutyrate infused intravenously (200 mg/kg) either 10 min or 2 hrs after myocardial damage had been modelled and by emoxypin (4 mg/kg; 0.4 mg/kg) infused intravenously 30 min after the damage.
在患有心肌肾上腺素坏死的犬类实验中，研究了具有抗缺氧和抗氧化活性的药物，即羟丁酸钠和艾莫昔芬，对心肌功能状态的影响。在模拟心肌损伤后10分钟或2小时静脉注射羟丁酸钠（200毫克/千克），以及在损伤后30分钟静脉注射艾莫昔芬（4毫克/千克；0.4毫克/千克），均产生了显著的心脏保护作用。
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