Rivière Y
Unité de Virologie et Immunologie Cellulaire, Institut Pasteur, Paris, France.
Cell Mol Biol (Noisy-le-grand). 1994;40 Suppl 1:45-8.
A vigorous virus-specific cytotoxic response has been detected in individuals infected by the human immunodeficiency virus (HIV). ADCC and CTL activities specific to the envelope glycoproteins could be measured at the same time from the same donor. CTL response have been shown directed to most viral structural and non-structural proteins. The p24gag protein is the most frequent target of HIV-specific CTL. The characterization of CTL epitopes at the level of the human population is of importance for vaccine strategy. The mechanism of control of virus replication by CD8+ T lymphocytes is not elucidated but HIV-specific CTL have been shown to mediate this antiviral activity. The biological relevance of CTL in vivo is discussed.
在感染人类免疫缺陷病毒（HIV）的个体中检测到了强烈的病毒特异性细胞毒性反应。可以从同一供体同时测量针对包膜糖蛋白的抗体依赖的细胞介导的细胞毒性（ADCC）和细胞毒性T淋巴细胞（CTL）活性。已显示CTL反应针对大多数病毒结构和非结构蛋白。p24gag蛋白是HIV特异性CTL最常见的靶标。在人群水平上对CTL表位进行表征对于疫苗策略很重要。CD8 + T淋巴细胞控制病毒复制的机制尚未阐明，但已证明HIV特异性CTL可介导这种抗病毒活性。文中讨论了CTL在体内的生物学相关性。
