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关于ADP在增强环孢素对线粒体膜通透性转换的抑制作用中的作用。

On the role of ADP to increase the inhibitory effect of cyclosporin on mitochondrial membrane permeability transition.

作者信息

Zazueta C, Reyes-Vivas H, Corona N, Bravo C, Chávez E

机构信息

Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F., México.

出版信息

Biochem Mol Biol Int. 1994 May;33(2):385-92.

PMID:7951056
Abstract

This work reports an investigation which demonstrate that the addition of ADP is necessary to attain the protective effect of cyclosporin on the carboxyatractyloside-induced mitochondrial Ca2+ release. Evidence are presented which indicate that the effect of ADP is exerted by increasing the inhibitory action of cyclosporin on the enzyme cyclophilin.

摘要

这项研究报告了一项调查，该调查表明添加二磷酸腺苷（ADP）对于实现环孢素对羧基苍术苷诱导的线粒体钙离子释放的保护作用是必要的。文中提供的证据表明，ADP的作用是通过增强环孢素对亲环蛋白的抑制作用来实现的。

相似文献

1
On the role of ADP to increase the inhibitory effect of cyclosporin on mitochondrial membrane permeability transition.关于ADP在增强环孢素对线粒体膜通透性转换的抑制作用中的作用。
Biochem Mol Biol Int. 1994 May;33(2):385-92.
2
Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase.环孢素抑制Ca2+诱导的肝脏和心脏线粒体大幅度肿胀，可能是由于该抑制剂与线粒体基质肽基脯氨酰顺反异构酶结合，阻止其与腺嘌呤核苷酸转位酶相互作用所致。
Biochem J. 1990 May 15;268(1):153-60. doi: 10.1042/bj2680153.
3
Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.环孢素A可减轻创伤性脑损伤后的急性线粒体功能障碍。
Exp Neurol. 1999 Nov;160(1):226-34. doi: 10.1006/exnr.1999.7197.
4
Fatty acid-induced Ca(2+)-dependent uncoupling and activation of external pathway of NADH oxidation are coupled to cyclosporin A-sensitive mitochondrial permeability transition.脂肪酸诱导的Ca(2+)依赖性解偶联以及NADH氧化外部途径的激活与环孢菌素A敏感的线粒体通透性转换相关联。
Biochem Mol Biol Int. 1994 Apr;32(6):1147-55.
5
Palmitic acid opens a novel cyclosporin A-insensitive pore in the inner mitochondrial membrane.棕榈酸在内线粒体膜上打开了一个新的对环孢菌素A不敏感的孔道。
Arch Biochem Biophys. 2001 Feb 1;386(1):37-51. doi: 10.1006/abbi.2000.2194.
6
[The role of the ADP/ATP-antiporter in the inhibition of nonspecific permeability of the inner mitochondrial membrane by cyclosporin A].[ADP/ATP反向转运体在环孢素A抑制线粒体内膜非特异性通透性中的作用]
Biokhimiia. 1991 Mar;56(3):536-41.
7
Brain-derived respiring mitochondria exhibit homogeneous, complete and cyclosporin-sensitive permeability transition.
J Neurochem. 2004 May;89(3):715-29. doi: 10.1111/j.1471-4159.2004.02400.x.
8
Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane.线粒体通透性转换孔调节的最新进展；线粒体内膜上的一种环孢菌素敏感孔。
J Bioenerg Biomembr. 1994 Oct;26(5):509-17. doi: 10.1007/BF00762735.
9
An ADP-sensitive cyclosporin-A-binding protein in rat liver mitochondria.大鼠肝线粒体中一种对ADP敏感的环孢菌素A结合蛋白。
Eur J Biochem. 1994 Apr 1;221(1):261-8. doi: 10.1111/j.1432-1033.1994.tb18737.x.
10
Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+].促溶剂和增加的基质体积增强线粒体亲环蛋白与线粒体内膜的结合，并使线粒体通透性转换对[Ca2+]敏感。
Biochemistry. 1996 Jun 25;35(25):8172-80. doi: 10.1021/bi9525177.

引用本文的文献

1
The composition of the incubation medium influences the sensitivity of mitochondrial permeability transition to cyclosporin A.孵育培养基的成分会影响线粒体通透性转换对环孢素A的敏感性。
J Bioenerg Biomembr. 2003 Apr;35(2):149-56. doi: 10.1023/a:1023798120239.
2
Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome.16三体小鼠海马神经元中钙信号改变和线粒体缺陷：唐氏综合征模型
J Neurosci. 1998 Sep 15;18(18):7216-31. doi: 10.1523/JNEUROSCI.18-18-07216.1998.
3
On the protection by inorganic phosphate of calcium-induced membrane permeability transition.
无机磷酸盐对钙诱导的膜通透性转变的保护作用
J Bioenerg Biomembr. 1997 Dec;29(6):571-7. doi: 10.1023/a:1022483018482.