Kaeffer B
INRA, Laboratoire de Pathologie Infectieuse et Immunologie, Nouzilly, France.
Vet Res. 1994;25(5):425-41.
Immortal lymphoblastoid cell lines of B and T lineages have been derived from blood cell cultures of Duroc, Miniature (histocompatible) or unknown porcine breeds. The lymphoblast immortalization has been putatively attributed to an oncogenic virus belonging either to the Herpesviridae or to the Retroviridae groups. But a definitive proof of a viral etiology is still lacking, impeding some therapeutic use of tissue culture products secreted by these cell lines. Nevertheless, immortal cell lines have many advantages over finite ones, owing to their ease of maintenance in simple media and to the acquisition of an infinite lifespan. The different cell lines are mainly used to develop the hybridoma technology in this species for cytogenetics and xenogenic research.
B 细胞和 T 细胞系的永生性淋巴母细胞系已从杜洛克猪、小型（组织相容性）猪或未知猪种的血细胞培养物中获得。淋巴母细胞的永生化被推测归因于属于疱疹病毒科或逆转录病毒科的致癌病毒。但仍缺乏病毒病因的确切证据，这阻碍了这些细胞系分泌的组织培养产品的一些治疗用途。然而，永生细胞系比有限细胞系有许多优势，这得益于它们易于在简单培养基中维持以及获得了无限寿命。不同的细胞系主要用于该物种的杂交瘤技术，以进行细胞遗传学和异种研究。
