Fontana D, Rolle L, Del Noce G, Tamagnone A, Rosso C
Dipartimento di Scienze Cliniche e Biologiche dell'Università di Torino.
Arch Ital Urol Androl. 1994 Sep;66(4):195-9.
Intracavernous administration of vasoactive drugs induces an erection in absence of erotic stimuli; we can use this property in the study of impotent patients, inducing the appearance on an erection to examine it in all its phases (FIC Test). In case of the appearance of a good erection, the test should rule out the presence of a penile arterial disease or of a corpora-veno-occlusive deficiency. When the administration of the drug does not cause complete tumescence, it is very probable that the erectile dysfunction is caused by arterial vascular alterations or by organic disorders of veno-occlusion mechanism, but we cannot exclude for a certainty a psychogenic dysfunction. In fact an excessive noradrenergic autonomic control, as during stress condition, may limit FIC Test response. Therefore we hope that more efficacious molecules will be available in a near future. Nevertheless, we consider the opportunity of enclosing tests in the diagnostic algorithm of impotent patients to reveal an excessive adrenergic tone, such as, for example, psychological tests, study of cavernous potential, or intracavernous catecholamine dosage.
海绵体内注射血管活性药物可在无性欲刺激的情况下诱发勃起；我们可利用这一特性来研究阳痿患者，诱发勃起以检查其各个阶段（国际勃起功能指数试验）。如果出现良好勃起，该试验应排除阴茎动脉疾病或海绵体静脉闭塞功能不全的存在。当药物注射未引起完全肿胀时，勃起功能障碍很可能是由动脉血管改变或静脉闭塞机制的器质性疾病引起的，但我们不能肯定地排除心理性功能障碍。事实上，在应激状态下，如去甲肾上腺素能自主神经控制过度，可能会限制国际勃起功能指数试验的反应。因此，我们希望在不久的将来能有更有效的分子。然而，我们认为有必要在阳痿患者的诊断算法中纳入一些测试，以揭示肾上腺素能张力过高的情况，例如心理测试、海绵体潜能研究或海绵体内儿茶酚胺剂量测定。
