Aruldhas M M, Thampi L T, Kumari T M, Govindarajulu P
Department of Endocrinology, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, India.
Endocr J. 1994 Apr;41(2):207-12. doi: 10.1507/endocrj.41.207.
Effects of prolactin and bromocriptine on neutral and phospholipids of liver, adipose tissue and serum were studied in mature male bonnet monkeys. Hyperprolactinemia (ovine prolactin, 250 micrograms/kg body weight/day, i.p. for 30 days) elevated hepatic total lipids and phospholipids and decreased total and free cholesterol. While triacyl glycerol accumulated, mono-and diacyl glycerols diminished in liver and adipose tissues of prolactin treated monkeys. Concentrations of all phospholipid fractions, except sphingomyelin and cardiolipin in adipose tissue accrued in both tissues. Serum triacylglycerol, phosphatidyl ethanolamine, phosphatidyl choline and phosphatidyl inositol showed a significant increase in hyperprolactinaemic monkeys. Bromocriptine (1 mg/kg body weight/day for 30 days) treatment reduced serum phospholipids without altering hepatic or adipose tissue lipids. The present study indicates that hyperprolactinaemia leads to hyperlipidemia due to accretion of hepatic and adipose tissue triacyl glycerol and certain phospholipid fractions. Bromocriptine has a specific inhibitory effect on serum phospholipids.
在成年雄性冠叶猴中研究了催乳素和溴隐亭对肝脏、脂肪组织和血清中中性脂质和磷脂的影响。高催乳素血症（羊催乳素，250微克/千克体重/天，腹腔注射30天）使肝脏总脂质和磷脂升高，并降低总胆固醇和游离胆固醇。在接受催乳素治疗的猴子的肝脏和脂肪组织中，三酰甘油积累，单酰甘油和二酰甘油减少。除脂肪组织中的鞘磷脂和心磷脂外，两种组织中所有磷脂组分的浓度均增加。高催乳素血症猴子的血清三酰甘油、磷脂酰乙醇胺、磷脂酰胆碱和磷脂酰肌醇显著增加。溴隐亭（1毫克/千克体重/天，共30天）治疗可降低血清磷脂，而不改变肝脏或脂肪组织脂质。本研究表明，高催乳素血症由于肝脏和脂肪组织三酰甘油及某些磷脂组分的积累而导致高脂血症。溴隐亭对血清磷脂有特异性抑制作用。
