Jeyaraj D A, Govindarajulu P
Department of Endocrinology, University of Madras, Taramani, India.
Indian J Exp Biol. 1991 Dec;29(12):1140-1.
Administration of testosterone propionate (TP; 1 mg/kg body weight/day; im, for 30 days) to mature male bonnet monkeys, decreased total lipids, glyceride glycerol and cholesterol concentrations in hepatic tissue. The decrease in glyceride glycerol was due to decrease in monoacyl and triacyl glycerol. Both, free and esterified cholesterol were decreased after testosterone administration. Eventhough, total phospholipid was not significantly altered, phosphatidylserine and cardiolipin were increased, due to testosterone administration. Testosterone inhibited NADP-isocitrate dehydrogenase activity in liver. The findings suggest that testosterone acts as a lipolytic hormone and its action may be direct through its specific receptors in liver.
对成年雄性冠毛猕猴注射丙酸睾酮（TP；1毫克/千克体重/天；肌肉注射，持续30天），可降低肝脏组织中的总脂质、甘油酯甘油和胆固醇浓度。甘油酯甘油的降低是由于单酰甘油和三酰甘油的减少。注射睾酮后，游离胆固醇和酯化胆固醇均减少。尽管总磷脂没有显著变化，但由于注射睾酮，磷脂酰丝氨酸和心磷脂增加。睾酮抑制肝脏中的NADP-异柠檬酸脱氢酶活性。这些发现表明，睾酮作为一种脂解激素，其作用可能通过肝脏中的特定受体直接发挥。
