[掺入的¹³⁷铯对心肌收缩肾上腺素能控制机制的修饰作用]
[Modifying effect of incorporated 137Cs on the mechanism of adrenergic control of myocardial contraction].
作者信息
Lobanok L M, Bulanova K Ia, Gerasimovich N V, Sineleva M V, Miliutin A A
出版信息
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):651-6.
PMID:7951898
Abstract
Incorporated 137Cs (absorbed dose of 0.26 Gy) causes decrease of myocardial's contractile function and inotropic response to beta-adrenagonists effect, isoproterenol-stimulated adenylate cyclase activity and beta-adrenoreceptors affinity. Adrenergic effects, mediated by alpha-adrenergic structures on heart contractile function, on the contrary, become stronger, that is due to the increase of the receptors' density on sarcolemma surface.
摘要
掺入的137铯（吸收剂量为0.26戈瑞）会导致心肌收缩功能下降，以及对β-肾上腺素能激动剂效应、异丙肾上腺素刺激的腺苷酸环化酶活性和β-肾上腺素能受体亲和力的变力反应降低。相反，由α-肾上腺素能结构介导的对心脏收缩功能的肾上腺素能效应会增强，这是由于肌膜表面受体密度增加所致。
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