Terefe H, Blaschke G
Institute of Pharmaceutical Chemistry, University of Münster, Germany.
J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):238-42. doi: 10.1016/0378-4347(94)80094-4.
The plasma concentrations vs. time profiles of the enantiomers of halofantrine and its main metabolite N-desbutylhalofantrine have been determined in two healthy volunteers after a single oral administration of 500 mg of racemic halofantrine hydrochloride (Halfan). A solid-phase extraction method was used for the purification of the samples. The enantiomers of halofantrine and N-desbutylhalofantrine were determined simultaneously using chiral high-performance liquid chromatography on chiral stationary phases with fluorescence detection.
