Bievskiĭ A N
Mikrobiol Z. 1994 Mar-Apr;56(2):7-11.
It was revealed that the same dosages of quaternary ammonium derivatives, such as decamethoxin and cetyltrimethylammonium bromide, inhibited the respiratory chains and caused destruction of Pseudomonas aeruginosa under aerobic conditions more effectively than under anaerobic ones when anions of nitric acid were the terminal acceptors of electrons. It was also registered that Pseudomonas were able to dissimilatory nitrate reduction in the media under the polysaccharide layer that was produced by these bacteria: this fact possibly proves the possibility of survival of denitrifying bacteria in solutions with high concentrations of quaternary ammonium salts. The data obtained permit supposing that inhibitors of respiratory chains and oxidizers may be used as potentiators of the antimicrobial action of quaternary ammonium derivatives.
结果表明，当硝酸根离子作为电子的最终受体时，在需氧条件下，相同剂量的季铵衍生物，如十甲溴铵和十六烷基三甲基溴化铵，比在厌氧条件下更有效地抑制呼吸链并导致铜绿假单胞菌的破坏。还记录到，在这些细菌产生的多糖层下的培养基中，假单胞菌能够进行异化硝酸盐还原：这一事实可能证明了反硝化细菌在高浓度季铵盐溶液中生存的可能性。所获得的数据表明，呼吸链抑制剂和氧化剂可作为季铵衍生物抗菌作用的增效剂。
