Borisov V A, Frolov A F
Zh Mikrobiol Epidemiol Immunobiol. 1982 Mar(3):21-4.
Experimental study in mice has revealed that live virulent shigellae, in contrast to killed ones, suppress the secondary immune response to guinea pig splenocytes, manifested as delayed type hypersensitivity. This suppression is caused by disturbances in the process of the realization of the existing immunological memory: avirulent shigellae have been proved to cause no such effect.
对小鼠的实验研究表明，与灭活志贺氏菌相比，活的有毒力志贺氏菌会抑制对豚鼠脾细胞的二次免疫反应，表现为迟发型超敏反应。这种抑制是由现有免疫记忆实现过程中的紊乱引起的：已证明无毒力志贺氏菌不会产生这种效果。
