Laping N J, Teter B, Nichols N R, Rozovsky I, Finch C E
Neurogerontology Division, Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Brain Pathol. 1994 Jul;4(3):259-75. doi: 10.1111/j.1750-3639.1994.tb00841.x.
Levels of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament protein, are altered during development and aging, GFAP also responds dynamically to neurodegenerative lesions. Changes in GFAP expression can occur at both transcriptional and translational levels. Modulators of GFAP expression include steroids, cytokines, and growth factors. GFAP expression also shows brain region-specific responses to sex steroids and of astrocyte-neuronal interactions. The 5'-upstream sequences of rat, mouse, and human are compared for the presence of response elements that are candidates for transcriptional regulation of GFAP. We propose that the regulation of the GFAP gene has evolved a system of controls that allow integrated responses to neuroendocrine and inflammatory modulators.
胶质纤维酸性蛋白（GFAP）是一种星形胶质细胞特异性中间丝蛋白，其水平在发育和衰老过程中会发生变化，GFAP 对神经退行性病变也有动态反应。GFAP 表达的变化可发生在转录和翻译水平。GFAP 表达的调节因子包括类固醇、细胞因子和生长因子。GFAP 表达还显示出对性类固醇以及星形胶质细胞与神经元相互作用的脑区特异性反应。比较大鼠、小鼠和人类的 5'上游序列，以寻找作为 GFAP 转录调控候选的反应元件。我们提出，GFAP 基因的调控已经进化出一套控制系统，能够对神经内分泌和炎症调节因子做出综合反应。
