Newcomer J W, Miller L S, Faustman W O, Wetzel M W, Vogler G P, Csernansky J G
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110.
Br J Psychiatry. 1994 Jun;164(6):834-8. doi: 10.1192/bjp.164.6.834.
Patients developing neuroleptic-induced akathisia have been reported to show higher levels of psychopathology. We sought to replicate this finding and determine its symptom specificity. We confirmed a significant relationship between ratings of akathisia and total score on the Brief Psychiatric Rating Scale (BPRS) during both acute and maintenance neuroleptic treatment. Using stepwise regression models, BPRS anxious-depressive subscale scores were the strongest predictors of akathisia during both treatment conditions. Paranoid subscale scores predicted akathisia only during maintenance treatment. These results suggest that neuroleptic-induced dysphoria largely explains the relationship between akathisia and residual psychopathology during both acute and maintenance neuroleptic treatment.
据报道，出现抗精神病药所致静坐不能的患者表现出更高水平的精神病理学症状。我们试图重复这一发现并确定其症状特异性。我们证实在急性和维持性抗精神病药物治疗期间，静坐不能评分与简明精神病评定量表（BPRS）总分之间存在显著关系。使用逐步回归模型，在两种治疗情况下，BPRS焦虑抑郁分量表得分都是静坐不能的最强预测因子。偏执分量表得分仅在维持治疗期间可预测静坐不能。这些结果表明，抗精神病药所致烦躁不安在很大程度上解释了急性和维持性抗精神病药物治疗期间静坐不能与残留精神病理学之间的关系。
