Sadler G P, McGee S, Dallimore N S, Monypenny I J, Douglas-Jones A G, Lyons K, Horgan K
Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
Br J Surg. 1994 Sep;81(9):1315-7. doi: 10.1002/bjs.1800810918.
Fine-needle aspiration cytology (FNAC) plays a key role in the preoperative diagnosis of carcinoma of the breast but is less reliable in the diagnosis of infiltrating lobular carcinoma. The method of diagnosis was reviewed in 56 patients with lobular carcinoma who had attended screening and symptomatic clinics. In 29 patients FNAC results demonstrated malignant cells; 15 of these had palpable disease and the mean tumour size was 21 mm. In 27 patients FNAC failed to demonstrate malignant cells; 13 lesions were palpable and the mean tumour size was 23 mm. Ten patients were diagnosed by needle-core biopsy when FNAC was not diagnostic. FNAC may fail to diagnose even large lobular carcinoma and needle-core biopsy is strongly recommended in this situation.
细针穿刺细胞学检查（FNAC）在乳腺癌的术前诊断中起着关键作用，但在浸润性小叶癌的诊断中可靠性较低。对56例参加筛查和症状门诊的小叶癌患者的诊断方法进行了回顾。29例患者的FNAC结果显示有恶性细胞；其中15例可触及病变，平均肿瘤大小为21毫米。27例患者的FNAC未能显示恶性细胞；13个病变可触及，平均肿瘤大小为23毫米。当FNAC不能确诊时，10例患者通过针芯活检得以诊断。即使是大的小叶癌，FNAC也可能无法诊断，在这种情况下强烈建议进行针芯活检。
