Hertrich I, Ackermann H
Department of Neurology, University of Tübingen, Germany.
Brain Lang. 1994 Aug;47(2):182-96. doi: 10.1006/brln.1994.1048.
Duration measurements at the acoustic speech signal of sentence utterances including syllable lengths, vowel durations, and voice-onset-time (VOT) were performed in 13 subjects with Huntington's disease (HD) and in 12 control speakers. First, all 13 HD subjects presented with increased variability of utterance duration and/or VOT. Second, a subgroup had reduced speech tempo concomitant with overproportional lengthening of short vowels. Presumably, these deviations result from slowed movement execution (bradykinesia) and delayed between-movement transitions. Third, durational parameters of phonetic timing, e.g. stress contrast, were largely unimpaired. In a further patient (HD14) severely reduced articulatory accuracy did not allow acoustic measurements. He presented with truncated, barely intelligible, diphthongized sentence utterances. A slight tendency for these deviations could be noted in two of the HD subjects who underwent acoustic analysis. Since all three subjects had a rather long disease duration, this constellation might represent an advanced stage of HD dysarthria into which the other syndromes ultimately will develop.
对13名患有亨廷顿舞蹈症（HD）的受试者和12名对照者的句子发音的声学语音信号进行了时长测量，包括音节长度、元音时长和语音起始时间（VOT）。首先，所有13名HD受试者的发音时长和/或VOT的变异性均增加。其次，一个亚组的语速减慢，同时短元音过度延长。据推测，这些偏差是由运动执行减慢（运动迟缓）和运动间转换延迟导致的。第三，语音时长参数，如重音对比，在很大程度上未受损害。在另一名患者（HD14）中，严重降低的发音准确性使得无法进行声学测量。他的句子发音被截断，几乎难以理解，且出现了双元音化。在接受声学分析的两名HD受试者中可以注意到这些偏差有轻微的趋势。由于所有这三名受试者的病程都相当长，这种情况可能代表了HD构音障碍的晚期阶段，其他综合征最终都会发展成这个阶段。
