猫中黑质对投射至前额叶皮质的背内侧核神经元的抑制性输入。

The inhibitory input from the substantia nigra to the mediodorsal nucleus neurons projecting to the prefrontal cortex in the cat.

作者信息

Miyamoto Y, Jinnai K

机构信息

Department of Neurosurgery, Shiga University of Medical Science, Japan.

出版信息

Brain Res. 1994 Jun 27;649(1-2):313-8. doi: 10.1016/0006-8993(94)91079-0.

DOI:10.1016/0006-8993(94)91079-0

PMID:7953647

Abstract

The effects of stimulation of the substantia nigra pars reticulata (SNr) on the neurons of the mediodorsal nucleus (MD) projecting to the prefrontal cortex (PF) were studied in cats. The MD neurons projecting to the ventral part of the PF tended to be located in the ventral part of the MD, while those projecting to the dorsal part of the PF in the dorsal part. Spontaneous discharges of 30/57 tested MD neurons were suppressed by SNr stimulation at a latency ranging from 2 to 15 ms. The latency of the suppression corresponded well to that of antidromic responses of SNr neurons elicited by MD stimulation (from 1.4 to 14.0 ms). Intracellular recordings in a few MD neurons showed IPSP by SNr stimulation. The SNr is considered to exert an inhibitory effect on the MD neurons projecting to the PF.

摘要

在猫身上研究了刺激黑质网状部（SNr）对投射到前额叶皮质（PF）的背内侧核（MD）神经元的影响。投射到PF腹侧部分的MD神经元倾向于位于MD的腹侧部分，而投射到PF背侧部分的MD神经元则位于MD的背侧部分。在57个被测试的MD神经元中，有30个的自发放电在2至15毫秒的潜伏期内被SNr刺激所抑制。抑制的潜伏期与MD刺激诱发的SNr神经元的逆向反应潜伏期（1.4至14.0毫秒）非常吻合。少数MD神经元的细胞内记录显示，SNr刺激可产生抑制性突触后电位（IPSP）。据认为，SNr对投射到PF的MD神经元发挥抑制作用。