荷包牡丹碱对仔猪吸气活动的影响。

Effects of bicuculline on inspiratory activities in piglets.

作者信息

Steele A M, Siddiqi Z A, Sica A L

机构信息

Department of Pediatrics, Schneider Children's Hospital, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, NY 10042.

出版信息

Brain Res. 1994 Jul 4;650(1):166-9. doi: 10.1016/0006-8993(94)90222-4.

DOI:10.1016/0006-8993(94)90222-4

PMID:7953670

Abstract

Antagonism of the alpha receptor sub-type at gamma-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABAA receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect on discharge amplitude was manifested in autopower spectra as an increase in the power of peaks located in the medium-frequency (10-50 Hz) band. More importantly, coherence estimates were increased by bicuculline administration demonstrating GABA-mediated influences on a central pattern generator with output in the 10-50 Hz band.

摘要

使用γ-氨基丁酸（GABA）受体拮抗剂荷包牡丹碱评估发育中仔猪α受体亚型在GABA识别位点的拮抗作用。荷包牡丹碱输注的作用是使膈神经和舌下神经放电幅度增加。这种荷包牡丹碱诱导的对放电幅度的影响在自功率谱中表现为位于中频（10 - 50Hz）频段的峰值功率增加。更重要的是，给予荷包牡丹碱后相干估计值增加，表明GABA对输出在10 - 50Hz频段的中枢模式发生器有介导影响。