Sica A L, Siddiqi Z A, Hundley B W, Gootman P M, Steele A M
Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, NY 11042.
Neurosci Lett. 1993 Oct 1;160(2):149-52. doi: 10.1016/0304-3940(93)90400-f.
In anesthetized kittens (< 1 to 24 days old), the effects of GABAA receptor antagonism on phrenic, hypoglossal and cervical sympathetic discharges were examined by i.v. bicuculline infusions during hyperoxia and hypoxia. Administration of bicuculline during hyperoxia produced marked increases in the amplitudes of inspiratory nerve discharges. During hypoxic stimulation (10% O2), the amplitudes of inspiratory activities decreased towards or below those observed during hyperoxia; bicuculline reversed this depression and restored inspiratory discharges. Our results indicated that GABAA receptors were functional shortly after birth, acting to mediate influences shaping inspiratory activity during hyperoxic breathing and during conditions of increased chemical drive.
在麻醉的幼猫（小于1至24日龄）中，通过在高氧和低氧期间静脉输注荷包牡丹碱，研究了GABAA受体拮抗作用对膈神经、舌下神经和颈交感神经放电的影响。在高氧期间给予荷包牡丹碱会使吸气神经放电幅度显著增加。在低氧刺激（10%氧气）期间，吸气活动的幅度朝着或低于高氧期间观察到的幅度下降；荷包牡丹碱逆转了这种抑制并恢复了吸气放电。我们的结果表明，GABAA受体在出生后不久就发挥作用，在高氧呼吸期间以及化学驱动增加的情况下，介导影响吸气活动的形成。
