Yen S J, Leu S Y, Hsu H
Department of Surgery, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Sep;54(3):166-9.
In addition to identifying and eradicating premalignant lesions, and detecting early cancer before the development of life-threatening consequences, new concepts and technological advances have stimulated a hightened interest in the secondary prevention of colorectal cancer.
People whose first degree relatives have had colorectal cancer are considered to run a higher risk of developing colorectal carcinoma. A screening program was carried out for 358 first degree relatives of colorectal cancer patients using colonoscopic screening.
The mean age of these first degree relatives was 44 years, ranging from 13 to 78 years. Two hundred and eleven (58.9%) of them were asymptomatic. Totally 73 polyps were detected in 53 subjects (14.9%). Two cancer lesions were identified. Thirty polyps (41.1%) measured between 0.5 cm and 2.0 cm. The polyps were mostly located in the rectum and sigmoid colon (63%). One polyp was found in a subject below 30 years of age. Over the age of 30, the incidence of polyp increased dramatically.
Our results confirmed that the screening program for the first degree relatives of patients with colorectal cancer is worthwhile. The program would have a more significant impact if the screening could start from subjects around the age of 30.
除了识别和消除癌前病变，以及在危及生命的后果出现之前检测早期癌症外，新的概念和技术进步激发了人们对结直肠癌二级预防的更高兴趣。
一级亲属患有结直肠癌的人被认为患结直肠癌的风险更高。对358名结直肠癌患者的一级亲属进行了结肠镜筛查的筛查项目。
这些一级亲属的平均年龄为44岁，年龄范围为13至78岁。其中211人（58.9%）无症状。共在53名受试者（14.9%）中检测到73个息肉。发现了2个癌性病变。30个息肉（41.1%）大小在0.5厘米至2.0厘米之间。息肉大多位于直肠和乙状结肠（63%）。在一名30岁以下的受试者中发现了一个息肉。30岁以上，息肉的发生率急剧增加。
我们的结果证实，对结直肠癌患者的一级亲属进行筛查项目是值得的。如果筛查能从30岁左右的受试者开始，该项目将产生更显著的影响。
