一名乳腺癌患者在接受氟尿嘧啶、多柔比星、亚叶酸钙、环磷酰胺和白细胞介素-3化疗后发生急性动脉血栓形成。
Acute arterial thrombosis in a patient with breast cancer after chemotherapy with 5-fluorouracil, doxorubicin, leucovorin, cyclophosphamide, and interleukin-3.
作者信息
Theodossiou C, Kroog G, Ettinghausen S, Tolcher A, Cowan K, O'Shaughnessy J
机构信息
Warren Grant Magnuson Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
Cancer. 1994 Nov 15;74(10):2808-10. doi: 10.1002/1097-0142(19941115)74:10<2808::aid-cncr2820741011>3.0.co;2-v.
BACKGROUND
Interleukin-3 (IL-3) is an experimental agent used to ameliorate neutropenia in patients receiving chemotherapy. Arterial thrombotic episodes after use of IL-3 have not been reported previously.
METHODS
The case of a patient with Stage III adenocarcinoma of the breast who developed hypotension and acute cerebellar artery and superior mesenteric artery thrombosis after receiving chemotherapy and treatment with IL-3 is reported.
RESULTS
To the authors' knowledge, this is the first patient with arterial thrombosis reported after treatment with IL-3.
CONCLUSIONS
Interleukin-3 may be associated with increased propensity for thrombosis.
背景
白细胞介素-3（IL-3）是一种用于改善接受化疗患者中性粒细胞减少的实验性药物。此前尚未有使用IL-3后发生动脉血栓事件的报道。
方法
报告了一名患有III期乳腺腺癌的患者，在接受化疗和IL-3治疗后出现低血压、急性小脑动脉和肠系膜上动脉血栓形成的病例。
结果
据作者所知，这是首例使用IL-3治疗后发生动脉血栓的患者。
结论
白细胞介素-3可能与血栓形成倾向增加有关。
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