Lichtenstein A V, Shapot V S
Biochem J. 1976 Dec 1;159(3):783-94. doi: 10.1042/bj1590783.
A model of cytoplasm-governed transcription is presented. The nuclear membrane has a selective permeability towards nuclear pre-mRNA molecules which are provided with group-specific non-translated "passwords". RNA transcription on the chromatin proceeds under a dual control. One of them is gene regulation according to the Britten-Davidson and Georgiev models. The other is cytoplasm-governed regulation mediated through the selective transport of mRNA from nucleus to cytoplasm. Pre-mRNA molecules which are not "in immediate demand" by the cytoplasm and therefore accumulating the nucleus repress their own synthesis by end-product inhibition. The interrelationship of the two types of regulation in the course of cell development is discussed.
提出了一种细胞质调控转录的模型。核膜对带有特定基团非翻译“密码”的核前体mRNA分子具有选择性通透性。染色质上的RNA转录在双重控制下进行。其中之一是根据布里顿 - 戴维森模型和乔治耶夫模型进行的基因调控。另一种是通过mRNA从细胞核到细胞质的选择性转运介导的细胞质调控。未被细胞质“即时需要”从而在细胞核中积累的前体mRNA分子通过终产物抑制来抑制自身的合成。讨论了细胞发育过程中两种调控类型的相互关系。
