Page D L, Lagios M D
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232-2561.
Cancer Lett. 1994 Oct 28;86(1):1-4. doi: 10.1016/0304-3835(94)90173-2.
The therapy of ductal carcinoma in situ is controversial, but is being more and more decided by the pathologic evidence. What we know of the natural history of ductal carcinoma in situ is that the comedo and non-comedo examples seem quite different. As detailed in several reviews, the information from studies following patients after biopsy alone indicate a great difference between the small non-comedo examples of ductal carcinoma in situ and the larger comedo DCIS. The currently available evidence from cases which have been treated by planned surgical excision without radiation therapy would indicate that the non-comedo examples of DCIS may be adequately treated by this modality as indicated in several recent studies.
导管原位癌的治疗存在争议，但越来越多地由病理证据来决定。我们对导管原位癌自然史的了解是，粉刺型和非粉刺型病例似乎有很大不同。正如在几篇综述中详细阐述的那样，仅活检后对患者进行随访研究的信息表明，导管原位癌的小非粉刺型病例与较大的粉刺型导管原位癌之间存在很大差异。目前来自未经放射治疗而接受计划性手术切除病例的现有证据表明，正如最近几项研究所表明的，非粉刺型导管原位癌病例可能通过这种方式得到充分治疗。
