Wettrell K, Pandolfi M
Br J Ophthalmol. 1976 Oct;60(10):680-3. doi: 10.1136/bjo.60.10.680.
Placebo and propranolol (Inderal) in doses of 20, 40, and 80 mg were given in a single-blind test to two groups of six ocular hypertensives. The groups consisted of patients with an intraocular pressure ranging from 20 to 29 mmHg and 30 to 39 mmHg. The doses were given 48 hours apart and administered after fasting 12 hours. IOP by Goldmann applanation tonometer, systemic blood pressure and pulse rate in the supine position were recorded hourly before and after administration. In both groups a decrease in mean IOP was noted after one hour and this reduction reached its maximum three hours after the administration of propranolol. The absolute reduction was greater in the group with the highest initial IOP and in both groups the fall in mean IOP showed a clear dose-dependent correlation. The simultaneous mean decrease in pulse rate was also dose-correlated, but reached its maximum two hours after administration. The fall in systemic blood pressure was only moderate and showed no obvious dose-dependence.
在一项单盲试验中，对两组各6名眼压过高患者给予安慰剂和剂量分别为20毫克、40毫克和80毫克的普萘洛尔（心得安）。这两组患者的眼压范围分别为20至29毫米汞柱和30至39毫米汞柱。给药间隔48小时，且在禁食12小时后进行。使用戈德曼压平眼压计每小时记录给药前后仰卧位的眼压、全身血压和脉搏率。两组在给药1小时后均观察到平均眼压下降，且在给予普萘洛尔3小时后这种下降达到最大幅度。初始眼压最高的组绝对降幅更大，且两组平均眼压的下降均呈现明显的剂量依赖性关系。同时，脉搏率的平均下降也与剂量相关，但在给药2小时后达到最大幅度。全身血压仅适度下降，且未表现出明显的剂量依赖性。
