Wettrell K
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Sep 30;204(1):1-7. doi: 10.1007/BF02387411.
Propranolol, pilocarpine, and placebo were tested on eight patients with ocular hypertension. The trial was performed in a randomized double-masked cross-over manner utilizing the double dummy technique. After 1 week's treatment with 40 mg propranolol administered orally twice daily a statistically significant decrease in intraocular pressure (IOP) was seen. Also after application of 2% pilocarpine eyedrops three times a day IOP was significantly reduced. Propranolol decreased the IOP to about the same extent as pilocarpine. Simultaneous administration of propranolol and pilocarpine caused a further decrease in IOP which was statistically significant compared with the corresponding values during administration of pilocarpine alone. The combination of pilocarpine and propranolol lowered IOP slightly more than propranolol alone. The difference was not, however, statistically significant. During treatment with propranolol a significant decrease in heart rate was observed and a slight reduction of systemic blood pressure. It is concluded that propranolol can additively decrease IOP during treatment with pilocarpine.
对8名高眼压患者进行了普萘洛尔、毛果芸香碱和安慰剂测试。该试验采用双盲双模拟技术以随机双盲交叉方式进行。每天口服2次40毫克普萘洛尔治疗1周后，眼压（IOP）出现统计学上的显著下降。每天3次应用2%毛果芸香碱滴眼液后眼压也显著降低。普萘洛尔降低眼压的程度与毛果芸香碱大致相同。普萘洛尔和毛果芸香碱同时给药导致眼压进一步下降，与单独使用毛果芸香碱期间的相应值相比具有统计学意义。毛果芸香碱和普萘洛尔联合使用降低眼压的幅度略大于单独使用普萘洛尔。然而，差异无统计学意义。在使用普萘洛尔治疗期间，观察到心率显著下降，全身血压略有降低。得出的结论是，普萘洛尔在与毛果芸香碱联合治疗期间可额外降低眼压。
