垂体细胞中白细胞介素-10产生及作用的证据。
Evidence for the production and action of interleukin-10 in pituitary cells.
作者信息
Hughes T K, Cadet P, Rady P L, Tyring S K, Chin R, Smith E M
机构信息
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77550.
出版信息
Cell Mol Neurobiol. 1994 Feb;14(1):59-69. doi: 10.1007/BF02088589.
Abstract
- Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neuroendocrine system involving these two substances. 2. Murine pituitary tumor cells (AtT-20) were found to produce up to 3 ng/ml of IL-10. 3. Pituitary cell corticotropin production was enhanced by IL-10 treatment. 4. IL-10 induced the production of ACTH in mouse splenocytes. 5. Authenticity of pituitary-derived IL-10 was shown by the demonstration of identical nucleic acid sequences of reverse-transcribed, polymerase chain reaction amplified fragments of cDNA obtained from murine splenocytes, a murine pituitary tumor cell line, and freshly isolated murine pituitaries.
摘要
- 白细胞介素-10（IL-10）在免疫系统中具有广泛的活性，如调节γ-干扰素（IFN-γ）和抗体产生。神经肽激素促肾上腺皮质激素（ACTH）具有类似的活性，这表明在免疫系统和神经内分泌系统之间存在一种涉及这两种物质的双向通信机制。2. 发现小鼠垂体肿瘤细胞（AtT-20）可产生高达3 ng/ml的IL-10。3. 通过IL-10处理可增强垂体细胞促肾上腺皮质激素的产生。4. IL-10诱导小鼠脾细胞产生ACTH。5. 通过对从小鼠脾细胞、小鼠垂体肿瘤细胞系和新鲜分离的小鼠垂体中获得的逆转录、聚合酶链反应扩增的cDNA片段的核酸序列进行鉴定，证明了垂体来源的IL-10的真实性。
相似文献
1
Evidence for the production and action of interleukin-10 in pituitary cells.垂体细胞中白细胞介素-10产生及作用的证据。
Cell Mol Neurobiol. 1994 Feb;14(1):59-69. doi: 10.1007/BF02088589.
2
Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide.
Proc Natl Acad Sci U S A. 1990 Feb;87(3):1057-60. doi: 10.1073/pnas.87.3.1057.
3
Presence of interleukin-10 transcripts in human pituitary and hypothalamus.
Cell Mol Neurobiol. 1995 Apr;15(2):289-96. doi: 10.1007/BF02073335.
4
Modulation of interleukin-1 receptors in the brain-endocrine-immune axis by stress and infection.应激和感染对脑-内分泌-免疫轴中白细胞介素-1受体的调节作用。
Brain Behav Immun. 1995 Dec;9(4):276-91. doi: 10.1006/brbi.1995.1027.
5
Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor alpha-chain-like molecule on pituitary cells.白细胞介素-2诱导促肾上腺皮质激素分泌：垂体细胞上存在一种白细胞介素-2受体α链样分子。
J Neuroimmunol. 1989 Feb;21(2-3):249-54. doi: 10.1016/0165-5728(89)90181-1.
6
Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis.白细胞介素-11刺激促肾上腺皮质激素细胞中阿黑皮素原基因表达及促肾上腺皮质激素分泌：下丘脑-垂体-肾上腺轴中细胞因子冗余网络的证据
Endocrinology. 1999 Apr;140(4):1559-66. doi: 10.1210/endo.140.4.6636.
7
Growth hormone-releasing peptide-2 stimulates secretion and synthesis of adrenocorticotropic hormone in mouse pituitary.生长激素释放肽-2刺激小鼠垂体中促肾上腺皮质激素的分泌和合成。
Regul Pept. 2009 Nov 27;158(1-3):116-20. doi: 10.1016/j.regpep.2009.07.018. Epub 2009 Aug 12.
8
Leukemia inhibitory factor modulates interleukin-1beta-induced activation of the hypothalamo-pituitary-adrenal axis.白血病抑制因子调节白细胞介素-1β诱导的下丘脑-垂体-肾上腺轴的激活。
Endocrinology. 1998 May;139(5):2201-8. doi: 10.1210/endo.139.5.6017.
9
Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression.人癌细胞系白细胞介素-10的产生及其与白细胞介素-6表达的关系。
Int J Cancer. 1993 Aug 19;55(1):96-101. doi: 10.1002/ijc.2910550118.
10
IL-10 as a mediator in the HPA axis and brain.
J Neuroimmunol. 1999 Dec;100(1-2):140-8. doi: 10.1016/s0165-5728(99)00206-4.
引用本文的文献
1
Gene Rs1800871, Rs1800872, and Rs1800896 Polymorphisms and IL-10 Serum Levels Association with Pituitary Adenoma.基因Rs1800871、Rs1800872和Rs1800896多态性与白细胞介素-10血清水平与垂体腺瘤的关联
Biomedicines. 2022 Aug 8;10(8):1921. doi: 10.3390/biomedicines10081921.
2
Interleukin-10: a key cytokine in depression?白细胞介素-10：抑郁症中的关键细胞因子？
Cardiovasc Psychiatry Neurol. 2009;2009:187894. doi: 10.1155/2009/187894. Epub 2009 Aug 16.
3
Infection, immunity and the neuroendocrine response.感染、免疫与神经内分泌反应。
Vet Immunol Immunopathol. 2009 Aug 15;130(3-4):141-62. doi: 10.1016/j.vetimm.2009.01.013. Epub 2009 Feb 4.
4
Paracrinicity: the story of 30 years of cellular pituitary crosstalk.旁分泌作用：30年细胞间垂体相互作用的故事
J Neuroendocrinol. 2008 Jan;20(1):1-70. doi: 10.1111/j.1365-2826.2007.01616.x.
5
Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin.白细胞介素-10调节下丘脑-垂体-肾上腺轴起源细胞中的基因表达。
Cell Mol Neurobiol. 2007 Mar;27(2):161-70. doi: 10.1007/s10571-006-9137-6. Epub 2007 Feb 13.
6
Cytokine regulation of tryptophan metabolism in the hypothalamic-pituitary-adrenal (HPA) axis: implications for protective and toxic consequences in neuroendocrine regulation.细胞因子对下丘脑 - 垂体 - 肾上腺（HPA）轴中色氨酸代谢的调节：对神经内分泌调节中保护和毒性后果的影响。
Cell Mol Neurobiol. 2005 Jun;25(3-4):673-80. doi: 10.1007/s10571-005-4007-1.
7
Genes expressed in the mouse pituitary corticotrope AtT-20/D-16v tumor cell line.在小鼠垂体促肾上腺皮质激素瘤AtT-20/D-16v肿瘤细胞系中表达的基因。
Pituitary. 2000 Nov;3(3):141-52. doi: 10.1023/a:1011491324117.
8
Presence of interleukin-10 transcripts in human pituitary and hypothalamus.
Cell Mol Neurobiol. 1995 Apr;15(2):289-96. doi: 10.1007/BF02073335.
本文引用的文献
1
Direct sequencing of consensus primer generated PCR fragments of human papillomaviruses.人乳头瘤病毒共有引物生成的PCR片段的直接测序。
J Virol Methods. 1993 Aug;43(3):335-50. doi: 10.1016/0166-0934(93)90151-g.
2
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.糖皮质激素在应激反应中的生理功能及其与药理作用的关系。
Endocr Rev. 1984 Winter;5(1):25-44. doi: 10.1210/edrv-5-1-25.
3
Regulation of lymphokine (gamma-interferon) production by corticotropin.促肾上腺皮质激素对淋巴因子（γ-干扰素）产生的调节作用。
J Immunol. 1984 Jan;132(1):246-50.
4
Regulation of the in vitro antibody response by neuroendocrine hormones.神经内分泌激素对体外抗体反应的调节
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4171-4. doi: 10.1073/pnas.79.13.4171.
5
Ia antigen: a murine B lymphocyte receptor for transformed cell induction of interferon-alpha/beta.Ia抗原：一种用于转化细胞诱导α/β干扰素的小鼠B淋巴细胞受体。
J Immunol. 1983 Oct;131(4):1895-9.
6
Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis.垂体切除小鼠中病毒诱导的皮质酮：一种可能的淋巴-肾上腺轴。
Science. 1982 Dec 24;218(4579):1311-2. doi: 10.1126/science.6183748.
7
Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.人类淋巴细胞促肾上腺皮质激素和内啡肽样物质的产生：与白细胞干扰素的关联。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7530-4. doi: 10.1073/pnas.78.12.7530.
8
Corticotropin releasing factor induction of leukocyte-derived immunoreactive ACTH and endorphins.促肾上腺皮质激素释放因子诱导白细胞衍生的免疫反应性促肾上腺皮质激素和内啡肽。
Nature. 1986;321(6073):881-2. doi: 10.1038/321881a0.
9
Corticotropin-releasing activity of monokines.
Science. 1985 Nov 29;230(4729):1035-7. doi: 10.1126/science.2997929.
10
Proopiomelanocortin-derived peptides in the immune system.免疫系统中源自阿片-促黑素细胞皮质素原的肽类。
Clin Endocrinol (Oxf). 1985 Jun;22(6):823-7. doi: 10.1111/j.1365-2265.1985.tb00173.x.
Zotero 插件