Couso J P, Martinez Arias A
Department of Zoology, University of Cambridge, England.
Cell. 1994 Oct 21;79(2):259-72. doi: 10.1016/0092-8674(94)90195-3.
Mutations in the Notch (N) gene affect many processes during the development of Drosophila. Some alleles of Notch affect only particular processes, suggesting that the Notch protein (N) has more than one functional domain. We have found a series of N mutant phenotypes that are similar to those produced by the loss of function of the segment polarity gene wingless (wg) in the embryo and the adult. In addition, we observe that mutations in N behave as dominant enhancers of wg and that there exist allele-specific interactions between the two loci. Our results suggest that the product of wg is a ligand for N.
Notch（N）基因的突变会影响果蝇发育过程中的许多进程。Notch的一些等位基因仅影响特定进程，这表明Notch蛋白（N）具有多个功能域。我们发现了一系列N突变体表型，这些表型与胚胎和成虫中节段极性基因无翅（wg）功能丧失所产生的表型相似。此外，我们观察到N基因的突变表现为wg的显性增强子，并且两个基因座之间存在等位基因特异性相互作用。我们的结果表明，wg的产物是N的配体。
