[Effects of nifedipine on hepatic hyaluronic acid, hydroxyproline and glucosaminidase contents in rats with liver fibrosis].

In early stage treatment groups, Nifedipine (Nif) could significantly reduce hepatic hyaluronic acid (HA) and hydroxyproline (Hyp) contents in rats in which liver fibrosis had been induced by CCl4 treatment. N-acetyl-beta-glucosaminidase (beta-NAG) activity showed a similar change in the high dosage group. In late stage treatment groups, HA was reduced markedly, and decreased beta-NAG levels were noted in the high dosage group. These effects on HA, Hyp and beta-NAG were dependent on Nif dosage. The results suggest that Nif could inhibit the development of liver fibrosis in rats, and may even reverse it.