[云南南部恶性疟原虫对甲氟喹、奎宁、阿莫地喹、氯喹、咯萘啶及磺胺多辛/乙胺嘧啶的体外敏感性]
[In vitro sensitivity of Plasmodium falciparum to mefloquine, quinine, amodiaquine, chloroquine, pyronaridine and sulfadoxine/pyrimethamine in south Yunnan].
作者信息
Yang H, Yang P, Yang Y
机构信息
Institute of Malaria Prevention and Treatment of Yunnan Province, Simao.
出版信息
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(2):140-2.
The sensitivity of P. falciparum to mefloquine, quinine, amodiaquine, chloroquine, pyronaridine, and sulfadoxine/pyrimethamine (MEF, QNN, AMO, CHL, PYR, S/P) was tested using in vitro microtest in south Yunnan Province in 1992. The ID50 were 46, 480, 52, 150, 15 and 2 x 10(4)/25 x 10(2) nmol/L, respectively; ID95 were 160, 1,536, 292, 680, 60 and 24 x 10(5)/3 x 10(5) nmol/L, respectively. All the isolates (30) were sensitive to MEF and QNN; 100% (30/30) and 96.7% (29/30) isolates were found to be resistant to AMO and CHL, the cross-resistance rate was 100% to the two drugs. One of 5 isolates exhibited resistance to PYR. The results suggest that the P. falciparum was susceptible to MEF and QNN, but was resistant to AMO, CHL and S/P. CHL-resistant P. falciparum showed a marked cross-resistance to AMO, but not to MEF, QNN, and S/P; AMO-resistant P. falciparum exhibited cross-resistance to CHL, but not to MEF, QNN, and S/P.
1992年在云南省南部采用体外微量试验检测了恶性疟原虫对甲氟喹、奎宁、氨酚喹、氯喹、咯萘啶和磺胺多辛/乙胺嘧啶（MEF、QNN、AMO、CHL、PYR、S/P）的敏感性。ID50分别为46、480、52、150、15和2×10(4)/25×10(2)nmol/L；ID95分别为160、1536、292、680、60和24×10(5)/3×10(5)nmol/L。所有分离株（30株）对MEF和QNN敏感；发现100%（30/30）和96.7%（29/30）的分离株对AMO和CHL耐药，两种药物的交叉耐药率为100%。5株分离株中有1株对PYR耐药。结果表明，恶性疟原虫对MEF和QNN敏感，但对AMO、CHL和S/P耐药。耐CHL的恶性疟原虫对AMO有明显的交叉耐药性，但对MEF、QNN和S/P无交叉耐药性；耐AMO的恶性疟原虫对CHL有交叉耐药性，但对MEF、QNN和S/P无交叉耐药性。
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