Manapat A E, McCarthy P M, Lytle B W, Taylor P C, Loop F D, Stewart R W, Rosenkranz E R, Sapp S K, Miller D, Cosgrove D M
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195.
Circulation. 1994 Nov;90(5 Pt 2):II144-7.
Internal thoracic artery (ITA) conduits are known to provide long-term patency and increased patient survival with low morbidity after coronary artery bypass grafting (CABG). Excellent clinical results with the ITA have stimulated interest in additional arterial grafts.
To review our experience and evaluate postoperative complications associated with these new conduits, from May 1985 to September 1993, we studied 290 patients who underwent CABG using additional arterial conduits. The right gastroepiploic artery (GEA) was used in 152 patients and the inferior epigastric artery (IEA) was used in 130 patients. Eight patients with both GEA and IEA grafts were excluded. Patient records were analyzed as to preoperative characteristics, angiographic findings, operative data, and postoperative complications. Statistical analysis was done using the Pearson chi 2 statistic and the t test. Ninety-eight percent of patients received one concomitant ITA graft, and the majority of patients in both groups had bilateral ITA grafts. The GEA group had a higher proportion of reoperations (GEA group, 54%; IEA group, 16%; P < .001), previous myocardial infarction (MI) (GEA group, 67%; IEA group, 50%; P = .004) and New York Heart Association class IV (GEA group, 28%; IEA group, 6%; P = .001). The IEA group was generally slightly older (IEA group, 56 years; GEA group, 52 years; P = .001). Hospital mortality (GEA group, 4%; IEA group, 0.8%) and postoperative morbidity (mediastinal bleeding, infection, stroke, MI, and low cardiac output) were not significantly different between the two groups or from our experience with routine CABG using the ITA. Three intraabdominal complications occurred in the GEA group: 2 episodes of bleeding and 1 of pancreatitis. One patient in the IEA group had abdominal wall bleeding. With overall short follow-up, angiographic patency in a small number of patients has been good: 80% for the GEA group and 85.7% for the IEA group.
We conclude that the morbidity associated with these additional arterial conduits is low and is comparable with that associated with routine CABG using the ITA. Currently we use the ITA for primary targets and alternative arterial conduits for vessels of secondary importance or when the ITA and/or saphenous vein is not available.
已知胸廓内动脉(ITA)移植物在冠状动脉旁路移植术(CABG)后可提供长期通畅性,并提高患者生存率,且发病率较低。ITA取得的优异临床效果激发了人们对其他动脉移植物的兴趣。
为回顾我们的经验并评估与这些新移植物相关的术后并发症,我们研究了1985年5月至1993年9月期间接受CABG并使用其他动脉移植物的290例患者。152例患者使用了右胃网膜动脉(GEA),130例患者使用了腹壁下动脉(IEA)。排除8例同时使用GEA和IEA移植物的患者。对患者记录进行分析,内容包括术前特征、血管造影结果、手术数据和术后并发症。使用Pearson卡方检验和t检验进行统计分析。98%的患者接受了一根ITA同期移植物,两组中的大多数患者都有双侧ITA移植物。GEA组再次手术的比例更高(GEA组为54%;IEA组为16%;P<0.001),既往有心肌梗死(MI)的比例更高(GEA组为67%;IEA组为50%;P = 0.004),纽约心脏协会心功能IV级的比例更高(GEA组为28%;IEA组为6%;P = 0.001)。IEA组患者的年龄总体略大(IEA组为56岁;GEA组为52岁;P = 0.001)。两组之间的医院死亡率(GEA组为4%;IEA组为0.8%)和术后发病率(纵隔出血、感染、中风、MI和低心排血量)与我们使用ITA进行常规CABG的经验相比无显著差异。GEA组发生了3例腹部并发症:2例出血和1例胰腺炎。IEA组有1例患者发生腹壁出血。由于总体随访时间较短,少数患者的血管造影通畅情况良好:GEA组为80%,IEA组为85.7%。
我们得出结论,这些其他动脉移植物相关的发病率较低,与使用ITA进行常规CABG相关的发病率相当。目前,我们将ITA用于主要目标血管,将替代动脉移植物用于次要血管或在无法使用ITA和/或大隐静脉时使用。