去甲肾上腺素能α-1和α-2拮抗剂可阻断左旋多巴诱导的新生大鼠空中踏步行为。
Noradrenergic alpha-1 and alpha-2 antagonists block L-dopa-induced air-stepping in neonatal rats.
作者信息
Taylor L L, Sickles A E, Stehouwer D J, Van Hartesveldt C
机构信息
Department of Psychology, University of Florida, Gainesville 32611.
出版信息
Brain Res Dev Brain Res. 1994 Jun 17;79(2):242-8. doi: 10.1016/0165-3806(94)90128-7.
Five-day-old rat pups suspended in air and administered L-3,4-dihydroxyphenylalanine (L-DOPA) engage in a highly stereotyped and coordinated locomotor behavior termed air-stepping. L-DOPA is a precursor for dopamine and noradrenaline and one or both of these neurotransmitters could play a role in L-DOPA-induced air-stepping. The role of noradrenaline was investigated by assessing the abilities of the alpha-1 noradrenergic receptor antagonist prazosin and the alpha-2 noradrenergic receptor antagonist idazoxan to block L-DOPA-induced air-stepping in 5-day-old rats. Both antagonists decreased the duration of air-stepping. In addition, prazosin altered the topography of air-stepping by interfering with coordination of the hindlimbs. The results suggest that alpha-1 and alpha-2 noradrenergic receptor subtypes are involved in L-DOPA-induced air-stepping.
将5日龄的幼鼠悬吊在空中并给予L-3,4-二羟基苯丙氨酸（L-DOPA）后，它们会表现出一种高度刻板且协调的运动行为，称为空中踏步。L-DOPA是多巴胺和去甲肾上腺素的前体，这两种神经递质中的一种或两种可能在L-DOPA诱导的空中踏步中发挥作用。通过评估α-1肾上腺素能受体拮抗剂哌唑嗪和α-2肾上腺素能受体拮抗剂咪唑克生阻断5日龄大鼠L-DOPA诱导的空中踏步的能力，研究了去甲肾上腺素的作用。两种拮抗剂均缩短了空中踏步的持续时间。此外，哌唑嗪通过干扰后肢的协调性改变了空中踏步的形态。结果表明，α-1和α-2肾上腺素能受体亚型参与了L-DOPA诱导的空中踏步。
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