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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Dennington P M, Berndt M C

Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1994 May;21(5):349-58. doi: 10.1111/j.1440-1681.1994.tb02527.x.

The thrombin receptor has now been cloned and found to be a member of the G-protein-coupled seven-transmembrane domain receptor family. 2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor-derived peptides have demonstrated that this receptor may be the one responsible for many of the actions of thrombin in platelets, endothelial cells, smooth muscle cells, fibroblasts, mesangial cells and neural cells. 3. The receptor appears to be activated by the novel mechanism of cleavage by thrombin to yield a new N-terminus which then interacts with the receptor as a tethered ligand to initiate cell activation.

凝血酶受体现已被克隆出来，发现它是G蛋白偶联的七跨膜结构域受体家族的一员。2. 该受体已在血小板、内皮细胞和平滑肌细胞中直接检测到，使用受体衍生肽的研究表明，该受体可能是负责凝血酶在血小板、内皮细胞、平滑肌细胞、成纤维细胞、系膜细胞和神经细胞中许多作用的受体。3. 该受体似乎是通过凝血酶切割这一新型机制被激活的，切割后产生一个新的N端，然后该N端作为一种拴系配体与受体相互作用，从而启动细胞激活。

Dennington P M, Berndt M C

Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1994 May;21(5):349-58. doi: 10.1111/j.1440-1681.1994.tb02527.x.

The thrombin receptor has now been cloned and found to be a member of the G-protein-coupled seven-transmembrane domain receptor family. 2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor-derived peptides have demonstrated that this receptor may be the one responsible for many of the actions of thrombin in platelets, endothelial cells, smooth muscle cells, fibroblasts, mesangial cells and neural cells. 3. The receptor appears to be activated by the novel mechanism of cleavage by thrombin to yield a new N-terminus which then interacts with the receptor as a tethered ligand to initiate cell activation.

凝血酶受体现已被克隆出来，发现它是G蛋白偶联的七跨膜结构域受体家族的一员。2. 该受体已在血小板、内皮细胞和平滑肌细胞中直接检测到，使用受体衍生肽的研究表明，该受体可能是负责凝血酶在血小板、内皮细胞、平滑肌细胞、成纤维细胞、系膜细胞和神经细胞中许多作用的受体。3. 该受体似乎是通过凝血酶切割这一新型机制被激活的，切割后产生一个新的N端，然后该N端作为一种拴系配体与受体相互作用，从而启动细胞激活。