Moudgil K D, Sercarz E E
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024-1489.
Clin Immunol Immunopathol. 1994 Dec;73(3):283-9. doi: 10.1006/clin.1994.1200.
Developing T cells potentially directed against cryptic self determinants escape tolerance induction in the thymus and thereby enrich the T cell repertoire. Cryptic self peptides become expressed at inflammatory tissue sites which can lead to engagement of this repertoire, leading to induction and/or perpetuation of autoimmune reactivity. On the other hand, expression of cryptic self determinants on tumor cells can be useful in generating effective anti-tumor immunity. This self-directed T cell repertoire can also be activated silently to induce memory and participate unexpectedly in responses to foreign antigens and is responsible for molecular mimicry. Finally, peptides containing cryptic determinants can be utilized for peptide-based immunotherapy.
发育中的T细胞可能针对隐蔽的自身决定簇，逃避胸腺中的耐受性诱导，从而丰富T细胞库。隐蔽的自身肽在炎症组织部位表达，这可能导致该细胞库的激活，进而导致自身免疫反应性的诱导和/或持续存在。另一方面，肿瘤细胞上隐蔽自身决定簇的表达有助于产生有效的抗肿瘤免疫。这种自我导向的T细胞库也可以被静默激活以诱导记忆，并意外地参与对外来抗原的反应，还负责分子模拟。最后，含有隐蔽决定簇的肽可用于基于肽的免疫治疗。
