Meroni P L, Tincani A, Barcellini W, Del Papa N, Gambini D, Piona A, La Rosa L, Balestrieri G
Istituto di Medicina Interna, Malattie Infettive e Immunopatologia, University of Milan, Italy.
Clin Exp Rheumatol. 1994 Sep-Oct;12 Suppl 10:S43-7.
The association between antiphospholipid antibodies (aPL) and arterial or venous thrombosis, fetal loss and thrombocytopenia defines the so-called "antiphospholipid syndrome" (APS). Despite serial studies in recent years, a clear pathogenetic mechanism(s) has not yet been demonstrated. Several authors have investigated the interaction between aPL and the membranes of blood cells (endothelial cells and platelets) involved in coagulation. aPL is also thought to affect the balance between the procoagulant and anticoagulant states by interacting with plasma or tissue cofactors. Finally, the strong association between aPL and experimental animal models of fetal loss supports a direct pathogenetic role for aPL in inducing a poor pregnancy outcome in APS women.
抗磷脂抗体（aPL）与动脉或静脉血栓形成、胎儿丢失及血小板减少之间的关联定义了所谓的“抗磷脂综合征”（APS）。尽管近年来进行了一系列研究，但尚未证实明确的致病机制。几位作者研究了aPL与参与凝血的血细胞（内皮细胞和血小板）膜之间的相互作用。aPL还被认为通过与血浆或组织辅因子相互作用来影响促凝和抗凝状态之间的平衡。最后，aPL与胎儿丢失的实验动物模型之间的密切关联支持了aPL在导致APS女性不良妊娠结局中具有直接致病作用。
