Aron A L, Gharavi A E, Shoenfeld Y
Department of Medicine, LSU Medical Center, New Orleans.
Int Arch Allergy Immunol. 1995 Jan;106(1):8-12. doi: 10.1159/000236883.
Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible mechanisms of action of antiphospholipid (aPL) antibodies. Apparently, aPL antibodies act by interfering with coagulation, involving both endothelial cells, platelets, and humoral components, and affect pregnancy outcome by interfering with embryo implantation and fetal development.
抗磷脂抗体综合征（APS）的特征是血清中存在针对带负电荷磷脂的自身抗体，临床症状为多发性血栓形成、血小板减少和反复流产。这些抗体导致临床表现的机制尚不清楚。我们回顾了抗磷脂（aPL）抗体可能的作用机制。显然，aPL抗体通过干扰凝血发挥作用，涉及内皮细胞、血小板和体液成分，并通过干扰胚胎着床和胎儿发育影响妊娠结局。
