Szathmáry I, Selmeci L, Szobor A, Molnár J
Department of Neurology, Hungarian State Railways, Szanatórium, Budapest.
Clin Neuropathol. 1994 Jul-Aug;13(4):181-4.
Forty patients with myasthenia gravis were tested for polyamine content of the musculus sternothyreoideus removed during thymectomy. Cases with slight muscle alteration were found to show elevated values for all the three polyamines (putrescine, spermidine and spermine) examined with an increased spermidine/spermine ratio. In severe muscular atrophy, however, the high spermidine and spermine levels were accompanied by unchanged putrescine content and spermidine/spermine ratio. Denervational changes in polyamine levels parallel to the degree of muscular damage are useful indicators of the actual grade of muscle atrophy associated with myasthenia gravis. In histologically intact samples, without apparent signs of muscular atrophy the spermidine level and spermidine/spermine ratio were increased in comparison to the control. In addition to being very early signs of denervation, these higher values are possibly the biochemical expression of some adaptive, compensatory hyperfunction of the muscle fibers.
对40例重症肌无力患者在胸腺切除术中切除的胸骨甲状肌进行了多胺含量检测。发现肌肉轻度改变的病例中，所检测的三种多胺（腐胺、亚精胺和精胺）含量均升高，亚精胺/精胺比值增加。然而，在严重肌肉萎缩的病例中，亚精胺和精胺水平较高，但腐胺含量及亚精胺/精胺比值未变。多胺水平的去神经变化与肌肉损伤程度平行，是重症肌无力相关肌肉萎缩实际程度的有用指标。在组织学上完整、无明显肌肉萎缩迹象的样本中，与对照组相比，亚精胺水平及亚精胺/精胺比值升高。这些较高的值除了是去神经的非常早期迹象外，可能还是肌肉纤维某些适应性、代偿性高功能的生化表现。
