Kalloo A N, Sostre S, Meyerrose G E, Pasricha P J, Szabo Z
Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287.
Clin Nucl Med. 1994 Aug;19(8):713-9.
Thirty consecutive patients with intact gallbladders and biliary pain were evaluated to determine whether gallbladder ejection fraction could identify sphincter of Oddi dysfunction. The mean gallbladder ejection fraction was 45% in patients with abdominal pain and 72% in normal controls. Gallbladder ejection fractions were then correlated with endoscopically measured sphincter of Oddi pressures in patients with abdominal pain. The mean gallbladder ejection fraction was 41% in 7 patients with elevated sphincter pressures and 46% in 23 patients with normal pressures (P = NS). Thirty-six percent of patients with elevated pressures and 33% of patients with normal pressures had abnormal gallbladder ejection fractions. Gallbladder ejection fraction had a sensitivity of 33%, a specificity of 63%, and a positive predictive value of 25% for detection of elevated pressures. Regression analysis revealed a poor correlation between sphincter pressure and gallbladder ejection fraction (r2 = 0.02). These findings suggest that gallbladder ejection fraction cannot be used to diagnose sphincter of Oddi dysfunction in patients before they undergo cholecystectomy.
对30例胆囊完整且有胆绞痛的连续患者进行评估，以确定胆囊排空分数是否能识别Oddi括约肌功能障碍。腹痛患者的平均胆囊排空分数为45%，正常对照组为72%。然后将腹痛患者的胆囊排空分数与内镜测量的Oddi括约肌压力进行相关性分析。括约肌压力升高的7例患者的平均胆囊排空分数为41%，压力正常的23例患者为46%（P=无显著性差异）。压力升高的患者中有36%、压力正常的患者中有33%的胆囊排空分数异常。胆囊排空分数检测压力升高的敏感性为33%，特异性为63%，阳性预测值为25%。回归分析显示括约肌压力与胆囊排空分数之间的相关性较差（r2=0.02）。这些发现表明，在患者接受胆囊切除术之前，胆囊排空分数不能用于诊断Oddi括约肌功能障碍。
