原发性和继发性免疫缺陷病中的白细胞迁移抑制因子（LMIF）概况
Leukocyte migration inhibitory factor (LMIF) profile in primary and secondary immunodeficiency disease.
作者信息
Górski A J, Dupont B, Hansen J A, O'Reilly R, Smithwick E, Górska R, Good R A
出版信息
Clin Exp Immunol. 1976 Dec;26(3):505-10.
Abstract
Lymphocytes from patients with primary and secondary immunodeficiency disease were tested for capacity to produce LMIF after mitogen and antigen stimulation as well as for ability to stimulate and respond in unidirectional MLC-LMIF assay. Different patterns of immune abnormality in vitro were detectable when Con A and Candida albicans antigen were used. In addition, significant abnormalities in LMIF responding and stimulatory capacity were demonstrated in patients with Hodgkin's disease. LMIF production after stimulation with different agents allows for a better characterization of cellular defects in immunodeficiency disease.
摘要
对原发性和继发性免疫缺陷病患者的淋巴细胞进行检测，以观察其在有丝分裂原和抗原刺激后产生淋巴细胞移动抑制因子（LMIF）的能力，以及在单向混合淋巴细胞培养-淋巴细胞移动抑制因子（MLC-LMIF）试验中的刺激和反应能力。当使用刀豆蛋白A（Con A）和白色念珠菌抗原时，可检测到体外不同模式的免疫异常。此外，霍奇金病患者在淋巴细胞移动抑制因子反应和刺激能力方面存在显著异常。用不同试剂刺激后产生淋巴细胞移动抑制因子，有助于更好地鉴定免疫缺陷病中的细胞缺陷。
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