Fasola E L, Moody J A, Shanholtzer C J, Peterson L R
Department of Laboratory Medicine, University of Minnesota, Minneapolis.
Diagn Microbiol Infect Dis. 1994 May;19(1):57-60. doi: 10.1016/0732-8893(94)90052-3.
Treatment of serious enterococcal infection involves the use of penicillin-aminoglycoside combination therapy if the aminoglycoside minimum inhibitory concentration (MIC) is < or = 2000 micrograms/ml, and the organism is susceptible to penicillin or ampicillin. We evaluated killing of 15 enterococci that differ in their susceptibility to gentamicin using time-kill studies at different gentamicin concentrations. Sensitive strains had a uniform population killed by gentamicin concentrations equal to or above the MIC. Low-level resistant strains (MIC > or = 8 but < or = 2000 micrograms/ml of gentamicin) had a diverse population with large numbers of cells killed at one-half the MIC, while the highly resistant strains (MIC > 2000 micrograms/ml) showed no killing by any concentration of gentamicin.
如果氨基糖苷类药物的最低抑菌浓度（MIC）≤2000微克/毫升，且该微生物对青霉素或氨苄西林敏感，则严重肠球菌感染的治疗涉及使用青霉素 - 氨基糖苷类联合疗法。我们使用不同庆大霉素浓度的时间杀菌研究评估了15株对庆大霉素敏感性不同的肠球菌的杀菌情况。敏感菌株在庆大霉素浓度等于或高于MIC时，菌群体被杀灭。低水平耐药菌株（庆大霉素MIC＞8但≤2000微克/毫升）的菌群多样，在MIC的一半浓度时大量细胞被杀灭，而高度耐药菌株（MIC＞2000微克/毫升）在任何浓度的庆大霉素下均未显示出杀菌效果。
