Ecavade A, Rao A R
Cancer Biology Laboratory, School of Life Sciences, Jawahar Lal Nehru University, New Delhi, India.
Contraception. 1994 Aug;50(2):175-83. doi: 10.1016/0010-7824(94)90053-1.
The present study reports the modulatory influence of oral contraceptive formulations, Ovral (0.05 mg ethinylestradiol plus 0.5 mg norgestrel per pill), Noracycline (0.05 mg ethinylestradiol plus 0.1 mg lynestrenol per pill), Pearl (0.03 mg ethinylestradiol plus 0.30 mg norgestrel) and Centchroman (30 mg), on the growth and developmental pattern of murine mammary epithelium in normal as well as ovariectomised mice. Oral treatments of ovariectomised mice for 15 days with doses D1 (1/5th of a pill) and D2 (1/10th of a pill) of Ovral, Noracycline and Pearl enhanced the diameter of the terminal end buds (TEBS) and lateral buds (LBS) significantly. The increase in the diameters of TEBS and LBS on treatment with similar doses of Centchroman were not much significant. Hence, it may be concluded from the present study that the growth and development pattern of mammary epithelium can be modulated by treatment with oral contraceptives Oral, Noracycline, Pearl and Centchroman which is indicated by the increase in the diameters of TEBS and LBS.
本研究报告了口服避孕药制剂奥炔诺（每片含0.05毫克炔雌醇加0.5毫克炔诺孕酮）、诺炔酮（每片含0.05毫克炔雌醇加0.1毫克利奈孕酮）、珍珠片（每片含0.03毫克炔雌醇加0.30毫克炔诺孕酮）和醋炔醚（30毫克）对正常及去卵巢小鼠乳腺上皮生长和发育模式的调节作用。对去卵巢小鼠连续15天口服奥炔诺、诺炔酮和珍珠片的D1剂量（一片的1/5）和D2剂量（一片的1/10），可显著增加末端终末芽（TEBS）和侧芽（LBS）的直径。用相似剂量的醋炔醚处理时，TEBS和LBS直径的增加不太显著。因此，从本研究可以得出结论，口服避孕药奥炔诺、诺炔酮、珍珠片和醋炔醚可调节乳腺上皮的生长和发育模式，这表现为TEBS和LBS直径的增加。
