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A region-specific microdissection library for human chromosome 2p23-->p21 and the analysis of an interstitial deletion of 2p21.

作者信息

Kao F T, Yu J, Qi J, Tong S, Muenke M

机构信息

Eleanor Roosevelt Institute for Cancer Research, Denver, CO.

出版信息

Cytogenet Cell Genet. 1995;68(1-2):17-8. doi: 10.1159/000133880.

DOI:10.1159/000133880
PMID:7956351
Abstract

A region-specific library of human chromosome 2p23-->p21 was constructed using microdissection and microcloning techniques. Analysis of 94 single-copy microclones from the library showed that 64% were derived from the dissected region. Ten microclones were further mapped to the 2p21 region using a patient with an interstitial deletion of 2p21 and displaying holoprosencephaly, an abnormal embryonic development in midbrain and midface.

摘要

相似文献

1
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