通过荧光原位杂交将人类ARF2和NCK基因以及其他13个NotI连接克隆定位于3号染色体。
Localization of human ARF2 and NCK genes and 13 other NotI-linking clones to chromosome 3 by fluorescence in situ hybridization.
作者信息
Vorobieva N, Protopopov A, Protopopova M, Kashuba V, Allikmets R L, Modi W, Zabarovsky E R, Klein G, Kisselev L, Graphodatsky A
机构信息
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk.
出版信息
Cytogenet Cell Genet. 1995;68(1-2):91-4. doi: 10.1159/000133898.
Two human genes containing NotI sites, ADP-ribosylation factor (ARF2) and melanoma NCK protein, were mapped by fluorescence in situ hybridization to 3p21.2-->p21.1 and 3q21, respectively. Thirteen other NotI-linking clones, representing sequence tagged sites, were also mapped to different regions of human chromosome 3. Two of these clones that contain sequences 80% homologous to the rat tropoelastin gene and brain Cl- channel protein CLC-2 gene probably represent new human genes closely related to the known rat genes.
两个含有NotI位点的人类基因，即ADP核糖基化因子（ARF2）和黑色素瘤NCK蛋白，通过荧光原位杂交分别定位到3p21.2→p21.1和3q21。另外13个代表序列标签位点的NotI连接克隆也被定位到人类染色体3的不同区域。其中两个克隆含有与大鼠原弹性蛋白基因和脑氯通道蛋白CLC-2基因80%同源的序列，可能代表与已知大鼠基因密切相关的新人类基因。
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