[蛇毒抗栓酶治疗急性心肌梗死溶栓效果的评估]
[The evaluation of thrombolytic effect of snake venom antithrombus enzyme in treatment of acute myocardial infarction].
作者信息
Zhang S Y, Jin L, Yan X W
机构信息
Department of Medicine, Peking Union Medical College Hospital, Beijing.
出版信息
Zhonghua Nei Ke Za Zhi. 1994 Apr;33(4):244-7.
To evaluate the thrombolytic effect of Snake Venom Antithrombus Enzyme (SVATE) in the treatment of early acute myocardial infarction (AMI), 52 cases with AMI were randomly allocated to three groups, control (22 cases), SVATE (15 cases), and Urokinase (15 cases). The results show that SVATE can inhibit platelet aggregation, activate slightly fibrinolytic system and decrease markedly plasma fibrinogen level. However, the thrombolytic effect of SVATE in early treatment of AMI is not ideal, it can be used in combination with effective thrombolytic drugs to prevent reocclusion and reinfarction in AMI.
为评估蛇毒抗栓酶（SVATE）治疗早期急性心肌梗死（AMI）的溶栓效果，将52例AMI患者随机分为三组，对照组（22例）、SVATE组（15例）和尿激酶组（15例）。结果显示，SVATE可抑制血小板聚集，轻度激活纤溶系统并显著降低血浆纤维蛋白原水平。然而，SVATE在早期治疗AMI时的溶栓效果并不理想，可与有效的溶栓药物联合使用，以预防AMI中的再闭塞和再梗死。
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