2型糖尿病患者的血小板纤溶酶原激活物抑制剂1
Platelet plasminogen activator inhibitor 1 in patients with type II diabetes.
作者信息
Jokl R, Laimins M, Klein R L, Lyons T J, Lopes-Virella M F, Colwell J A
机构信息
Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29401.
出版信息
Diabetes Care. 1994 Aug;17(8):818-23. doi: 10.2337/diacare.17.8.818.
OBJECTIVE
To compare platelet plasminogen activator inhibitor 1 (PAI-1) concentration in type II diabetic patients and healthy control subjects.
RESEARCH DESIGN AND METHODS
We studied a group of 12 diabetic patients whose disease was controlled by diet or sulfonylurea therapy and a group of 17 nondiabetic control subjects. All subjects were free of clinically advanced vascular disease. PAI-1 antigen concentrations were measured in 5 x 10(8) isolated platelets, which were lysed by 1% Triton X-100.
RESULTS
Mean platelet PAI-1 was significantly higher in diabetic patients (264 +/- 83 ng/5 x 10(8) platelets) compared with control subjects (202 +/- 71 ng/5 x 10(8) platelets) (P < 0.05). A significant independent positive correlation was found between platelet PAI-1 concentrations and fasting plasma specific insulin levels in the diabetic patients (r = 0.63, P = 0.03).
CONCLUSIONS
These findings suggest that 1) a higher platelet PAI-1 concentration may contribute to enhanced thrombosis in type II diabetes and 2) megakaryocyte PAI-1 synthesis may be under the control of insulin.
目的
比较2型糖尿病患者与健康对照者血小板纤溶酶原激活物抑制剂1（PAI-1）的浓度。
研究设计与方法
我们研究了一组12名通过饮食或磺脲类药物治疗控制病情的糖尿病患者以及一组17名非糖尿病对照者。所有受试者均无临床晚期血管疾病。通过1% Triton X-100裂解5×10⁸个分离的血小板，测量其中PAI-1抗原浓度。
结果
与对照者（202±71 ng/5×10⁸个血小板）相比，糖尿病患者的平均血小板PAI-1显著更高（264±83 ng/5×10⁸个血小板）（P<0.05）。在糖尿病患者中，血小板PAI-1浓度与空腹血浆特异性胰岛素水平之间存在显著的独立正相关（r = 0.63，P = 0.03）。
结论
这些发现表明：1）较高的血小板PAI-1浓度可能导致2型糖尿病患者血栓形成增加；2）巨核细胞PAI-1的合成可能受胰岛素调控。
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