Lee H C, Lee K W, Chung C H, Chung Y S, Lee E J, Lim S K, Kim K R, Huh K B, Lee S C, Kwon O W
Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Diabetes Res Clin Pract. 1994 Jun;24(2):85-8. doi: 10.1016/0168-8227(94)90024-8.
Vitreous fluid and serum were obtained at the time of vitrectomy from 15 subjects with diabetic proliferative retinopathy and 6 control subjects. The mean serum IGF-I (IGF-I level: 1 nM/l = 7.7 ng/ml) concentrations were 15.40 +/- 4.97 nM/l in controls and 16.24 +/- 4.32 nM/l in diabetic patients. The mean vitreous IGF-I concentration was 1.05 +/- 0.30 nM/l in controls and 0.91 +/- 0.50 nM/l in diabetic patients. There were no significant differences between the two groups, and serum IGF-I concentrations were not correlated with vitreous IGF-I concentrations in the patients with diabetic proliferative retinopathy. These data suggest that IGF-I may not be a risk factor for the development of proliferative diabetic retinpathy.
在玻璃体切割术时，从15名糖尿病性增殖性视网膜病变患者和6名对照受试者中获取了玻璃体液和血清。对照组血清IGF-I（IGF-I水平：1 nM/l = 7.7 ng/ml）的平均浓度为15.40±4.97 nM/l，糖尿病患者为16.24±4.32 nM/l。对照组玻璃体液IGF-I的平均浓度为1.05±0.30 nM/l，糖尿病患者为0.91±0.50 nM/l。两组之间无显著差异，且糖尿病性增殖性视网膜病变患者的血清IGF-I浓度与玻璃体液IGF-I浓度不相关。这些数据表明IGF-I可能不是增殖性糖尿病视网膜病变发生的危险因素。
