糖尿病增殖性视网膜病变患者血清和玻璃体液中的胰岛素样生长因子-I

IGF-I of serum and vitreous fluid in patients with diabetic proliferative retinopathy.

作者信息

Lee H C, Lee K W, Chung C H, Chung Y S, Lee E J, Lim S K, Kim K R, Huh K B, Lee S C, Kwon O W

机构信息

Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.

出版信息

Diabetes Res Clin Pract. 1994 Jun;24(2):85-8. doi: 10.1016/0168-8227(94)90024-8.

DOI:10.1016/0168-8227(94)90024-8

PMID:7956713

Abstract

Vitreous fluid and serum were obtained at the time of vitrectomy from 15 subjects with diabetic proliferative retinopathy and 6 control subjects. The mean serum IGF-I (IGF-I level: 1 nM/l = 7.7 ng/ml) concentrations were 15.40 +/- 4.97 nM/l in controls and 16.24 +/- 4.32 nM/l in diabetic patients. The mean vitreous IGF-I concentration was 1.05 +/- 0.30 nM/l in controls and 0.91 +/- 0.50 nM/l in diabetic patients. There were no significant differences between the two groups, and serum IGF-I concentrations were not correlated with vitreous IGF-I concentrations in the patients with diabetic proliferative retinopathy. These data suggest that IGF-I may not be a risk factor for the development of proliferative diabetic retinpathy.

摘要

在玻璃体切割术时，从15名糖尿病性增殖性视网膜病变患者和6名对照受试者中获取了玻璃体液和血清。对照组血清IGF-I（IGF-I水平：1 nM/l = 7.7 ng/ml）的平均浓度为15.40±4.97 nM/l，糖尿病患者为16.24±4.32 nM/l。对照组玻璃体液IGF-I的平均浓度为1.05±0.30 nM/l，糖尿病患者为0.91±0.50 nM/l。两组之间无显著差异，且糖尿病性增殖性视网膜病变患者的血清IGF-I浓度与玻璃体液IGF-I浓度不相关。这些数据表明IGF-I可能不是增殖性糖尿病视网膜病变发生的危险因素。